Nootropic agent
AssigneesSanten Pharmaceutical Co., Ltd., Daiichi Pharmaceutical Co., Ltd.
InventorsYasufumi Shirasaki, Shinichiro Ashida
Life of this patent
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Abstract
The present invention relates to a nootropic agent which comprises a derivative of 2-phenyl-3-oxo-2H-1,4-benzothiazine. This nootropic agent is effective for treating diseases accompanied by a lowering of cerebral functions, for instance, cerebral infarction disorders due to ischemia such as transitory cerebral ischemia, brain edema, cerebral disorders due to the after-effect such as cerebral hemorrhage, cerebral disorders due to traumatic injury such as bruise, central nervous degeneration and degenerative diseases such as dementia, mental disorders, neurosis and Alzheimer's diseases.
Claims4
A method for improving cerebral function which comprises administering an effective amount of a compound represented by Formula (I) or salts thereof to a patient suffering from a disease which is accompanied by a lowering of cerebral function:
- ##STR3## wherein R.sub.1 represents one or more functional groups selected from the group consisting of a hydrogen atom, a lower alkyl group, a halogen atom, a nitro group, a hydroxyl group, a lower alkylamino group and a lower alkoxycarbonyloxy group;
- R.sub.2 represents a hydrogen atom, a lower alkyl group or a cycloalkyl group having 3 to 6 carbon atoms;
- R.sub.3 represents one or more functional groups selected from the group consisting of a hydrogen atom, a lower alkyl group, a halogen atom, a nitro group, a hydroxyl group, a lower alkoxy group, a lower alkylenedioxy group, a lower alkanoyl group, a lower alkanoyloxy group, an amino group, a lower alkylamino group, a lower alkanoylamino group and a lower alkoxycarbonyloxy group, or a group:
- ##STR4## R.sub.4 represents a hydrogen atom or a lower alkyl group;
- A and B may be the same or different and each represents a lower alkylene group having 1 to 6 carbon atoms;
- and n is 3 or 4.
Dependencies are inferred from the claim text.