Stabilized aqueous preparation of active form of vitamin D.sub.3
AssigneeTeijin Limited
InventorsYuji Makino, Hideo Matugi, Yoshiki Suzuki
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Abstract
An aqueous preparation of active form of vitamin D.sub.3 which is solubilized with a nonionic surface active agent and stabilized with a combination of a specific chelating agent such as citric acid with an antioxidant. Stabilized oral and parenteral preparations of active form of vitamin D.sub.3 can be provided.
Claims7
An aqueous preparation of active form of vitamin D.sub.3, comprising the active form of Vitamin D.sub.3, a nonionic surface active agent, an antioxidant and at least one chelating agent selected from the group consisting of citric acid, tartaric acid and metal salts thereof,
- wherein the active form of Vitamin D.sub.3 is (i) solubilized with the nonionic surface active agent and (ii) stabilized with a combination of the antioxidant and the at least one chelating agent,
- wherein the amount of said at least one chelating agent is 100 to 10,000 parts by weight per 1 part by weight of the active form of Vitamin D.sub.3, and
- wherein the active form of vitamin D.sub.3 is at least one selected from the group consisting of 1.alpha.,24-dihydroxycholecalciferol, 1.alpha.-hydroxycholecalciferol, 1.alpha.,25-dihydroxycholecalciferol, and 1.alpha.,25-dihydroxycholecalciferol-26,23-lactone.
A method for preparing a stabilized aqueous preparation of active form of vitamin D.sub.3 comprising the steps of:
- preparing a thick solution of the active form of vitamin D.sub.3 in a nonionic surface active agent and adding said thick solution to an aqueous solution containing a combination of at least one chelating agent selected from the group consisting of citric acid, tartaric acid and metal salts and an antioxidant.
Dependencies are inferred from the claim text.