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US 5,182,272 AGranted
8-substituted-dibenz[b,f][1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides, pharmaceutical compositions, and methods for treating pain
AssigneeG. D. Searle & Co.
InventorsE. Ann Hallinan, Robert K. Husa, Karen B. Peterson
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Abstract
The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## wherein X is ##STR2## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
Claims28
A compound having the formula:
- ##STR55## or a pharmaceutically-acceptable salt thereof, wherein:
- Y is oxygen, sulfur, ##STR56## R.sup.1 is hydrogen, halogen or --CF.sub.3 ;
- R.sup.2 is hydrogen, halogen, --OH or --OCH.sub.3 ;
- R.sup.3 is hydrogen, alkyl, aryl, alkyl-substituted aryl or aryl-substituted alkyl;
- m is an integer of from 1 to 5;
- X is ##STR57## R.sup.4 is hydrogen, alkyl, aryl, alkyl-substituted aryl, trifluoromethyl-substituted aryl or aryl-substituted alkyl;
- and
- R.sup.5 and R.sup.6 are each independently hydrogen, alkyl, aryl, alkyl-substituted aryl or aryl-substituted alkyl wherein the term "aryl" used throughout the claim is defined to mean any of the following groups:
- phenyl, thienyl, furanyl, pyridinyl, imidazolyl, pyrimidyl, (is)oxazolyl, thiazolyl, triazolyl, tetrazolyl or pyrrolyl.
6 more elements
Dependencies are inferred from the claim text.