Stabilizing preparation for thymoxamine
AssigneeIolab Corporation
InventorsDonald G. Musson, Orest Olejnik
Life of this patent
Estimating the term…
Abstract
Experiments have been performed which test the stability of thymoxamine in aqueous solution at room temperature and above. It was determined that dimethyl-beta-cyclodextrin slows the hydrolysis degradation of thymoxamine while other beta-cyclodextrin analogs either accelerate the hydrolysis degradation or have no effect on the rate of hydrolysis degradation. Cytological experiments have been performed which show that chemical formulations containing thymoxamine and up to 5% by weight dimethyl-beta-cyclodextrin have the same toxicity as chemical formulations with thymoxamine alone.
Claims8
A chemical formulation for preventing hydrolysis of thymoxamine, comprising:
- a therapeutic quantity of thymoxamine hydrochloride;
- and
- a sufficient quantity of dimethyl-beta-cyclodextrin to form inclusion compounds with said thymoxamine.
Dependencies are inferred from the claim text.