Anti-cancer activity potentiator
AssigneesLederle (Japan), Ltd., Nisshin Flour Milling Co., Ltd.
InventorsOsamu Ogawa, Ikuo Kishi, Yoshiyuki Tahara, Masanori Sugita
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Abstract
A pharmaceutical oil-in-water type microemulsion having an action of potentiating the activities of anti-cancer agents, said micro-emulsion comprises fine particles of a vegetable oil or a triglyceride of a medium-chain fatty acid having 8 to 12 carbon atoms containing 0.1 to 10% (w/v) of N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl)ethylenediamine malate of formula (I) below, ##STR1## an aqueous medium, and 0.05 to 25% (w/v) of a physiologically acceptable phospholipid for dispersing said fine particles in said aqueous medium.
Claims6
A method of potentiating the anti-cancer activities of adriamycin which comprises intravenously administering to a warm-blooded animal an effective amount of adriamycin in combination with an effective amount of a micro-emulsion which comprises
- fine particles of a vegetable oil or a triglyceride of a medium-chain fatty acid having 8 to 12 carbon atoms containing 0.1 to 10% (w/v) of N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl)ethylenediamine malate of formula (I) below, ##STR4##
- in an aqueous medium, and 0. 05 to 25% (w/v) of a physiologically acceptable phospholipid for dispersing said fine particles in said aqueous medium.
Dependencies are inferred from the claim text.