Calmodulin binding peptide derivatives of non-erythroid alpha spectrin
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorThomas Leto
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Abstract
The present invention relates to a polypeptide and derivatives thereof deduced from the native structure of non-erythroid alpha spectrin and compositions thereof. One embodiment of the invention is 24 amino acids in length and composed of the following linear sequence of residues: Lys-Thr-Ala-Ser-Pro-Trp-Lys-Ser-Ala-Arg-Leu- Met-Val-His-Thr-Val-Ala-Thr-Phe-Asn-Ser-Ile-Lys-Glu. The invention further relates to methods of using the polypeptide, such as methods for treating disorders including prophylaxis against organ and tissue transplant rejection or treatment of autoimmune disorders.
Claims30
An isolated polypeptide which consists essentially of the following sequence:
- Lys-Thr-Ala-Ser-Pro-Trp-Lys-Ser-Ala-Arg-Leu-Met-Val-His-Thr-Val-Ala-Thr-Ph e-Asn-Ser-Ile-Lys-Glu, a calmodulin binding active derivative thereof having said sequence as its nucleus, or a calmodulin binding active derivative having single or multiple amino acid substitutions, deletions or insertions and having the calmodulin binding activity of said sequence.
An isolated polypeptide which consists essentially of the following sequence:
- Pro-Trp-Lys-Ser-Ala-Arg-Leu-Met-Val-His-Thr-Val-Ala-Thr-Phe, a calmodulin binding active derivative thereof having said sequence as its nucleus, or a calmodulin binding active derivative having single or multiple amino acid substitutions, deletions or insertions and having the calmodulin binding activity of said sequence.
An isolated polypeptide which consists essentially of the following sequence:
- Pro-Trp-Lys-Ser-Ala-Arg-Leu-Met-Val-His-Thr-Val-Ala-Thr-Phe or a calmodulin binding active derivative thereof having said sequence as its nucleus.
An isolated polypeptide which consists essentially of the following sequence:
- Lys-Thr-Ala-Ser-Pro-Trp-Lys-Ser-Ala-Arg-Leu-Met-Val-His-Thr-Val-Ala-Thr-Ph e-Asn-Ser-Ile-Lys-Glu or a calmodulin binding acting derivative thereof having said sequence as its nucleus.
Dependencies are inferred from the claim text.