Modified transforming growth factor alpha oligopeptides and pharmaceutical compositions thereof
AssigneeThe Rockefeller University
InventorJames P. Tam
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Abstract
This invention relates to transforming growth factor alpha modified by replacement of an L-amino acid residue with a D-amino acid residue and pharmaceutical compositions thereof useful in wound healing, ulcer treatment or trauma.
Claims20
Transforming growth factor .alpha. modified by replacement of an L-amino acid residue with a D-amino acid residue.
(D-Val-1) TGF.alpha..
(D-Val-2) TGF.alpha..
(D-Ser-3) TGF.alpha..
(D-Phe-5) TGF.alpha..
(D-Ser-11) TGF.alpha..
(D-Gln-14) TGF.alpha..
(D-Gln-26) TGF.alpha..
(D-Lys-29) TGF.alpha..
(D-Ala-50) TGF.alpha..
A pharmaceutical composition containing a therapeutically effective amount of transforming growth factor.alpha. modified by replacement of an L-amino acid residue with a D-amino acid residue together with a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.