Use of pure histones H1 and H2A:H2B dimers in therapeutic methods
AssigneeVolker Rusch
InventorsMichael Zeppezauer, Robert Reichhart
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Abstract
The invention relates to the use of pure histones H1, H2A, H2B, H2A:H2B, H3 as hormonal or hormon-like active substance for the preparation of pharmaceuticals for the immuno-therapy, for the therapy of endocrine disturbance and for cancer therapy. Instead of the histones also their evolutionary variable sections or at least one partial section of at least five aminoacid residues of at least one evolutionary variable histon section can be used.
Claims9
A therapeutic method for treatment of radiation-induced leukemia or carcinoma of a patient in need thereof which comprises administering to said patient a biological composition which comprises a therapeutically acceptable carrier and, in a quantity having a therapeutic effect, a biologically active pure histone consisting of H1 or histone dimer H2A:H2B.
A biologically active composition, which comprises a physiologically acceptable carrier and pure histone H1.
Dependencies are inferred from the claim text.