Fowlpox virus promoters
AssigneeNational Research Development Corporation
InventorsMatthew M. Binns, Michael E. G. Boursnell, Joan I. A. Campbell, Fiona M. Tomley
Life of this patent
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Abstract
Fowlpox virus (FPV) promoter DNA for use in expressing a foreign gene inserted in a FPV vector by homologous recombination, which comprises the promoter of any of the following FPV genes: (1) The FB4b gene which encodes a protein of about 657 amino acids in a sequence beginning ##STR1## (2) The BamHI fragment ORF8 gene encoding a protein of about 116 amino acids in a sequence beginning ##STR2## (3) The BamHI fragment ORF5 gene encoding a protein of about 105 amino acids in a sequence beginning ##STR3## (4) The BamHI fragment ORF10 gene encoding a protein of about 280 amino acids in a sequence beginning ##STR4##
Claims8
An isolated DNA consisting essentially of the promoter sequence which is located immediately 5' to an open reading frame in the fowlpox virus genome, said open reading frame being selected from the group consisting of:
- (1) The FB4b gene which is fowlpox virus encodes a protein of about 657 amino acids in a sequence beginning ##STR12## (2) The BamHI fragment ORF8 gene encoding a protein of about 116 amino acids in a sequence beginning ##STR13## (3) The BamHI fragment ORF5 gene encoding a protein of about 105 amino acids in a sequence beginning ##STR14## (4) The BamHI fragment ORF10 gene encoding a protein of about 280 amino acids in a sequence beginning ##STR15##
Recombinant DNA comprising the promoter sequence which is located immediately 5' to an open reading frame in the fowlpox virus genome, said open reading frame being selected from the group consisting of:
- (1) The FP4b gene which in fowlpox virus encodes a protein of about 657 amino acids in a sequence beginning ##STR17## (2) The BamHI fragment ORF8 gene encoding a protein of about 116 amino acids in a sequence beginning ##STR18## (3) The BamHI fragment ORF5 gene encoding a protein of about 105 amino acids in a sequence beginning ##STR19## (4) The BamHI fragment ORF10 gene encoding a protein of about 280 amino acids in a sequence beginning ##STR20## transcribably linked to a foreign gene.
Dependencies are inferred from the claim text.