Nucleotide sequences which are selectively expressed in pre-B cells and probes therefor
AssigneeHoffmann-La Roche Inc.
InventorsSteven R. Bauer, Akira Kudo, Georg F. Melchers, Nobuo Sakaguchi
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Abstract
The present invention provides nucleotide sequences which are selectively expressed in pre-B cells, probes comprising a polynucleotide hybridizing specifically to such a nucleotide sequence and methods for the production of such probes. These probes may be used for identifying pre-B cells. The invention further provides polypeptides translated from a transcript comprising a nucleotide sequence which is selectively expressed in pre-B cells or parts thereof, antibodies against these polypeptides and methods for the preparation and use of the polypeptides and antibodies raised against them.
Claims15
A polynucleotide which has the nucleotide sequence
- ______________________________________ GAGCTCTGCATGTCTGCACCATGTCCTGGGCT CCTGTCCTGCTCATGCACTTTGTCTACT GCACAGGTGAGGGAACCCCCAGATCCCAAAGA CTCCTGCCCCTTCCTTCATCCTGCCCTG CCCCCACGGGCCACATGCATCTGTGTCACCAG GTTGTGGTCCTCAGCCGGTGCTACATCA GCCGCCGGCCATGTCCTCGGCCCTTGGAACCA CAATCCGCCTCACCTGCACCC TGAGGAA CGACCATGACATCGGTGTGTACAGCGTCTACT GGTACCAGCAGAGGCCGGGCCACCCTCC CAGGTTCCTGCTGAGATATTTCTCACAATCAG ACAAGAGCCAGGGCCCCCAGGTCCCCCC TCGCTTCTCTGGATCCAAAGATGTGGCCAGGA ACAGGGGGTATTTGAGCATCTCTGAGCT GCAGCCTGAGGACGAGGCTATGTATTACTGTG CTATGGGGGCCCGCAGCTCGGAGAAGGA GGAGAGGGAGAGGGAGTGGGA GGAAGAAATGG AACCCACTGCAG. ______________________________________
- or a homologous or degenerate sequence thereof, or fragments of said polynucleotide, which fragments hybridize to nucleic acid sequences expressed in pre-B cells and not expressed in other types of cells.
A polynucleotide which has the nucleotide sequence
- __________________________________________________________________________ GGAATAGCTTTTGGCCACCAGAGGA GGAACAATCCTTTTGCCGGGAGATCTACACTGCAAGTGAGGCTAGAGTTGACTTTGGACT TGAGGGTCAATGAAGCTCAGAGTAGGACAGACTCTGGGCACTATCCCCAGGCAGTGTGAA GTTCTCCTCCTGCTGCTGCTGTTGGGTCTAGTGGATGGTGTCCACCACATACTTTCCCCA AGCTCAGCAGAAAGGAGCAGAGCTGTGGGCCCTGGAGCTTCAGTGGGAAGCAACAGGCCT AGCCTATGGGCCCTTCCCGGCAGGCTCCTGTTCCAGATCATCCCACGGGGAGCAGGTCCC AGGTGCTCGCCCCATAGGCTTCCATCTAAGCCCCAGTTTTGGTATGTCTTTGGTGGTGGG ACCCAGCTCACAATCCTAGGTCAGCCCAAGTCTGACCCCTTGGTCACTCTGTTCCTGCCT TCCTTAAAGAATCTTCAGCCAACAAGGCCACACGTAGTGTGTTTGGTGAGCGAATTCTAC CCAGGTACTTTGGTGGTGGACTGGAAGGTAGATGGGGTCCCTGTCACTCAGGGTGTAGAG ACAACCCAACCCTCCAAACAGACCAACAACAAATACATGGTCAGCAGCTACCTGACACTG ATATCTGACCAGTGGATGCCTCACAGTAGATACAGCTGCCGGGTCACTCATGAAGGAAAC ACTGTGGAGAAGAGTGTGTCACCTGCTGAGTGTTCTTAGAGCACAATCCTCCCTGAAGCC TCAGGGGCCTGGATCTGAAGTGCCAGAAAAAGTTGTTTTTTGTTTTGTTTTTTGTTTTTT TTCCCATTAACCATCTCACTGTCTTTCCTGTGCCTAATACTCAATAAATATCTTACCACC AACC. __________________________________________________________________________
- or a homologous or degenerate sequence thereof, or fragments of said polynucleotide, which fragments hybridize to nucleic acid sequences expressed in pre-B cells and not expressed in other types of cells.
A polynucleotide which has the nucleotide sequence
- __________________________________________________________________________ CCAGAAAGCCTGGGAGGGTGGTGAGCAGGAACCAGGGGTGCAGTGAC CCTCTCCCCAAAGCAGGGAGGAGAGTGCTTCCCAGCTGGTCAGGGCCCAGGAGCAGTGGC TGTAGGGGGCAGGGTGCTGCAGGTCTGGAGCCATGGCCTGGACGTCTGTCCTGCTCATGC TGCTGGCCTATCTCACAGGTTGTGGCCCTCAGCCCATGGTGCATCAGCCACCATTAGCAT CTTCTTCCCTTGGAGCCACCATCCGCCTCTCCTGTACCCTGAGCAACGACCATAACATTG GCATTTACAGCATTTACTGGTACCAGCAGAGGCCGGGCCACCCTCCCAGGTTCCTGCTGA GATACTTCTCACACTCAGACAAGCACCAGGGTCCCGATATCCCACCTCGCTTCTCCGGGT CCAAAGATACGACCAGGAACCTGGGGTATCTGAGCATCTCTGAACTGCAGCCTGAGGACG AGGCTGTGTATTACTGTGCCGTGGGGCTCCGGAGCCAGGAAAAGAAGAGGATGGAGAGGG AGTGGGAAGGAGAAAAGTCGTATACAGATTTGGGATCTTAGGCTCTGGAGACATTCAGAC CCTGAACTGAAGACAGAGTTTGCTTTGCTCGGCTAGTCTGGTATGGGAAGGAGGGGTAGA ACGTGAGGTTTTGCAGAGCCTAGAAGATGGAATTATGCAGCTTTTCCTTGTTCTGCGGTG TTGCTATGAGCCCCCATTGGAGGCTGGATTGTAGAATTAAAGCTGTTTTTACTG. __________________________________________________________________________
- or a homologous or degenerate sequence thereof, or fragments of said polynucleotide, which fragments hybridize to nucleic acid sequences expressed in pre-B cells and not expressed in other types of cells.
Dependencies are inferred from the claim text.