Pilosinine derivatives
AssigneeMerck Patent Gesellschaft mit beschraenkter Haftung
InventorsUlrich Heywang, Michael Casutt, Michael Schwarz
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Abstract
The invention relates to a process for the preparation of racemic pilosinine derivatives as precursor for the alkaloid pilocarpine of pharmacological importance from a 5-formyl-1-alkylimidazole of the formula I ##STR1## in which R.sup.1 is a straight-chain or branched alkyl chain with 1-6 C atoms which, via the stage of the thioacetal, is added onto .gamma.-crotonolactone.
Claims6
A compound which is a thioacetal of the formula II ##STR7## wherein R.sup.1 is a straight-chain or branched alkyl chain with 1-6 C atoms,
- R.sup.2 and R.sup.3 are each, identically or independently of one another, a low molecular weight alkyl group with 1-5 C atoms, phenylene or benzylene radicals optionally substituted by fluorine, chlorine, bromine, alkyl or alkoxy having up to 1-3 C atoms.
A compound which is a butyrolactone of the formula III ##STR8## wherein R.sup.1 is a straight chain or branched alkyl chain with 1-6 C atoms,
- R.sup.2 and R.sup.3 are each, identically or independently of one another, an alkyl group with 1-5 C atoms, phenylene or benzylene radicals optionally substituted by fluorine, chlorine, bromine, alkyl or alkoxy having up to 1-3 C atoms.
Dependencies are inferred from the claim text.