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US 5,180,826 AGranted
Process for the production of 1-(n-methanesulfonyl-n-methylaminosulfonyl)-3-(2-pyrimidyl) urea derivatives
AssigneeLonza Ltd.
InventorsGareth Griffiths, Aleksander Warm, Felix Previdoli, Gary Ryan
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Abstract
A process for the production of 1-(N-methanesulfonyl-N-methylaminosulfonyl)-3-(2-pyrimidyl) urea derivatives (MMSPH). In the process, methanesulfonylmethylamine (MMSA) is first converted with chlorosulfonylisocyanate (CSI) into a 1-methanesulfonyl-1-methyl-3-(N-methanesulfonyl-N-methylaminosulfonyl) urea derivative (MMMSH) and then the MMMSH is converted with a 2-aminopyridine into the end product.
Claims8
A process for the production of 1-(N-methanesulfonyl-N-methylaminosulfonyl)-3-(2-pyrimidyl) urea derivatives of the formula:
- ##STR6## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and each is a hydrogen atom, a C.sub.1 -C.sub.4 alkoxy group, a hydroxyl group or a halogen atom, comprising:
- in a first stage, converting methanesulfonylethyl amine of the formula:
- ##STR7## with chlorosulfonylisocyanate into a 1-methanesulfonyl-1-methyl -3-(N-methanesulfonyl-N-methylaminosulfonyl) urea derivative of the formula:
- ##STR8## and then, in a second stage, converting the 1-methanesulfonyl-1-methyl-3-(N-methanesulfonyl-N-methylaminosulfonyl) urea derivative with a 2-aminopyrimidine of formula:
- ##STR9## wherein R.sub.1, R.sub.2 and R.sub.3 have the above-mentioned meaning, into the end product.
2 more elements
Dependencies are inferred from the claim text.