Purified myeloblastin, nucleic acid molecule encoding same, and uses thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorYvon Cayre
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Abstract
This invention provides an isolated nucleic acid molecule encoding human myeloblastin, a nucleic acid probe for detecting myeloblastin, and an antisense oligodeoxynucleotide complementary to myeloblastin mRNA. The invention also provides antibodies directed to myeloblastin, and purified myeloblastin. The invention further provides a pharmaceutical composition to inhibit proliferation and induce differentiation of leukemia cells, a myeloblastin inhibitor, and a factor suppressing myeloblastin expression. The invention provides methods for identifying leukemia cells which express different quantities of myeloblastin, treating leukemia, and for preparing purified myeloblastin.
Claims13
An isolated nucleic acid molecule encoding a myeloblastin and having a coding sequence comprising the coding sequence shown in FIG. 1D.
An antisense oligonucleotide which is at least 15 nucleotides in length having a sequence complementary to a nucleic acid molecule encoding myeloblastin as shown in FIG. 1D.
Dependencies are inferred from the claim text.