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US 5,180,811 AGranted
Proteins having a TNF action comprising TNF-fibromectin fusion protein
AssigneeBASF SE
InventorsThomas Doerper, Achim Moeller, Heinz Hillen, Gerhard Keilhauer, Franz Emling, Lothar Daum
Life of this patent
Estimating the term…
Abstract
Derivatives of a tumor necrosis factor (TNF), which originate from a modification at the amino terminus of the TNF molecule are suitable for controlling diseases.
Claims2
A protein having the following amino acid sequence:
- ##STR8## in which n is 0, 1, 2, 3 or 4, X is -Tyr-Ala-Val-Thr-Gly-Arg-Gly-Asp -Ser-Pro-Ala-Ser-Ser-Lys-Pro-Ile-Ser-Ile-Asn-Tyr-Arg-Thr-Glu-Ile-Asp- or part thereof having sufficient length to bind to human fibronectin, and Y is a hydrogen atom or a methionine residue.
Dependencies are inferred from the claim text.