Aralkylamine compounds
AssigneeTakeda Chemical Industries, Ltd.
InventorsGiichi Goto, Akinobu Nagaoka, Yuji Ishihara
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Abstract
An aralkylamine compound of the formula ##STR1## wherein R.sup.1 means a hydrogen atom or a lower alkyl group; R.sup.2 means an aromatic group which may be substituted; R.sup.3 means a hydrogen atom, a lower alkyl group or an aromatic group which may be substituted; n means an integer of 0 to 7; ring A means a five-through eight-membered cyclic group which may be substituted and may contain one or two hetero atom(s) of O and S atoms as the ring-constituents; and ring B means a benzene ring which may be substituted, or a salt thereof, which is useful as an cholinesterase inhibitor and a cerebral function ameliorating agent.
Claims7
An aralkylamine compound of the formula ##STR80## wherein R.sup.1 means a hydrogen atom or a lower alkyl group;
- R.sup.2 means a phenyl or naphthyl optionally substituted with one or two C.sub.1-4 alkoxy groups;
- R.sup.3 means a hydrogen atom;
- n means an integer of 3, 4 or 5;
- ring A means a five-membered carbocyclic group optionally substituted by (i) hydroxyl, (ii) oxo or (iii) a phenyl group optionally substituted with one or two C.sub.1-2 alkoxy groups;
- and ring B means a benzene ring optionally substituted with one to three substituents selected from the group consisting of halogen, nitro, C.sub.1-4 alkoxy, and C.sub.1-4 alkylsulfonyl, or a physiologically acceptable salt thereof.
A compound which is 5,6-dimethoxy-2-[4-[N-ethyl-N-[(2-methoxyphenyl)methyl]amino]butyl]-1-inda none fumarate.
A compound which is 5,6-dimethoxy-2-[4-[N-ethyl-N-[(2-methoxyphenyl)methyl]-amino]propyl-1-ind anone fumarate.
A method of inhibiting cholinesterase in a patient which comprises administering to a mammal a cholinesterase inhibiting amount of 5,6-dimethoxy-2-[4-[N-ethyl-N-[(2-methoxyphenyl(methyl]-amino]propyl-1-ind anone fumarate.
Dependencies are inferred from the claim text.