Anti-inflammatory and analgesic compounds, related compositions and methods for preparation and use thereof
AssigneesXonex Laboratories, Inc., Toyobo Co., Ltd.
InventorsKazuo Watanabe, Toshio Tuchida, Duane R. Schultz
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Abstract
This application relates to an anti-inflammatory, immunosuppressive and analgesic composition, a method for its preparation, a pharmaceutical composition including it and a method of treating auto-immune diseases. The anti-inflammatory, immunosuppressive and analgesic compound is derived from ant venom extract which has been purified of contamination by a variety of non-active components present in crude ant venom extracts. A synthetic venom has also been prepared from various components. The related pharmaceutical composition has been shown to be effective in treating and alleviating the symptoms of auto-immune diseases, particularly rheumatoid arthritis.
Claims9
An aqueous composition comprising at least about 1,500 .mu.g/ml of ammonium chloride, at least about 1,200 .mu.g/ml of arginine, at least about 2,500 .mu.g/ml of choline chloride, at least about 700 .mu.g/ml of putrescine and at least about 500 .mu.g/ml of ethanolamine wherein said composition is capable of at least about 85% inactivation of C3 in normal human serum.
A method for treating rheumatoid arthritis in animals which comprises administering to an animal in need of said treatment an effective amount of a composition comprising ammonium chloride and arginine wherein said composition is capable of at least about 85% inactivation of C3 in normal human serum and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.