2- and 3-alkoxy or hydroxy-8-substituted-dibenz[b,f]-[1,4]oxazepine-10(11H)-carboxylic acid, substituted hydrazides and methods for treating pain
AssigneeG. D. Searle & Co.
InventorsRobert K. Husa, E. Ann Hallinan, Michel Lesne, Marc Herin
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Abstract
The present invention provides 2-, 3-, and 5- and/or 8-substituted, and/or side-chain substituted, dibenzoxazepine compounds of Formula I: ##STR1## wherein Y is sulfur, ##STR2## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
Claims12
A compound having the structure:
- ##STR18## or a pharmaceutically-acceptable salt thereof, wherein:
- R.sup.1 is:
- hydrogen or halogen;
- R.sup.2 is:
- hydroxy or alkoxy;
- Z is:
- oxygen, sulfur, ##STR19## m is:
- an integer of from 1 to 4;
- n is:
- an integer of from 1 to 4;
- and
- Y is:
- sulfur, ##STR20##
Dependencies are inferred from the claim text.