Adenosine compounds for the treatment of diseases caused by parasitic protozoa
AssigneeHealth Research, Inc.
InventorsJanice R. Sufrin, Cyrus J. Bacchi, Carl W. Porter, Henry Nathan, Arthur J. Spiess, Nigel Yarlett
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Abstract
The abstract isn’t available for this document.
Claims9
A compound selected from the group consisting of 5'-deoxy-5'-(monofluoroethylthio)adenosine (MFETA);
- 5'-deoxy-5'-(chloroethylthio)adenosine (CETA) and 5'-deoxy-5,-(bromoethylthio)adenosine (BETA).
The compound 5'-deoxy-5'-(monofluoroethylthio)adenosine (MFETA).
The compound 5'-deoxy-5'-(chloroethylthio)adenosine (CETA).
The compound 5'-deoxy-5'-(bromoethylthio)adenosine (BETA).
A method for treating infections caused by 5'-deoxy-5'-methylthioadenosine (MTA) phosphorylase-containing pathogenic microorganisms which comprises administering a nontoxic, effective amount of an adenosine compound to a human being or an animal in need of such a treatment, wherein said adenosine compound is selected from one or more of the following compounds:
- ' -deoxy-5'-(hydroxyethylthio)adenosine (HETA);
- 5'-deoxy-5'-(monofluoroethylthio)adenosine (MFETA);
- 5'-deoxy-5'-(chloroethylthio)adenosine (CETA);
- and
- 5'-deoxy-5'-(bromoethylthio)adenosine (BETA).
A method for treating infections caused by 5'-deoxy-5'-methylthioadenosine (MTA) phosphorylase-containing pathogenic microorganisms which comprises administering a nontoxic, effective amount of 5'-deoxy-5'-(hydroxyethylthio)adenosine to a human being or an animal in need of such a treatment.
A method for treating infections caused by Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense, which comprises administering a nontoxic, effective amount of an adenosine compound to a human being or an animal in need of such a treatment, wherein said adenosine compound is selected from one or more of the following compounds:
- ' -deoxy-5'-(hydroxyethylthio)adenosine (HETA);
- 5'-deoxy-5'-(monofluoroethylthio)adenosine (MFETA);
- 5'-deoxy-5'-(chloroethylthio)adenosine (CETA);
- and
- 5'-deoxy-5'-(bromoethylthio)adenosine (BETA).
A method for treating infections caused by Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense, which comprises administering a nontoxic, effective amount of 5'-deoxy-5'-(hydroxyethylthio)adenosine to a human being or an animal in need of such a treatment.
Dependencies are inferred from the claim text.