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US 5,180,712 AGranted
Petide antidementia and nootropic agents
AssigneesFujirebio Inc., Nippon Chemiphar Co., Ltd.
InventorsYoshikazu Isowa, Yoshiaki Sato, Yoshiharu Nakashima, Mitsuo Masaki, Norihisa Miyake, Masaki Uehara, Kenji Hirate
Life of this patent
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Abstract
A peptide having one of the following formulae (I), (II), (III) and (IV): ##STR1## or its functional derivatives, and a pharmaceutically acceptable salt thereof are disclosed. These peptides have a nootropic effect and are effective as antidementia agents.
Claims16
A peptide having the formula (I):
- ##STR15## or its derivative having an amide group at the terminal amino acid moiety, or a pharmaceutically acceptable salt thereof.
A peptide having the formula (II):
- pGlu--Asn--Cys--Pro--Arg--Gly (II)
- or its derivative having an amide group at the terminal amino acid moiety, or a pharmaceutically acceptable salt thereof.
A peptide having the formula (III):
- ##STR16## or its derivative having an amide group at the terminal amino acid moiety, or a pharmaceutically acceptable salt thereof.
A peptide having the formula (IV):
- Asn--Cys--Pro--Arg (IV)
- or its derivative having an amide group at the terminal amino acid moiety, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.