Pravastatin pharmaceuatical compositions having good stability
AssigneeE. R. Squibb & Sons, Inc.
InventorsYatindra M. Joshi, Pierina Chiesa, Nemichand B. Jain
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Abstract
A pharmaceutical composition is provided which has excellent stability, when dispersed in water has a pH of at least about 9, and includes a medicament which is sensitive to a low pH environment such as pravastatin, one or more fillers such as lactose and/or microcrystalline cellulose, one or more binders, such as microcrystalline cellulose (dry binder) or polyvinylpyrrolidone (wet binder), one or more disintegrating agents such as croscarmellose sodium, one or more lubricants such as magnesium stearate and one or more basifying agents such as magnesium oxide.
Claims12
A stabilized pravastatin composition, which comprises pravastatin and one or more basifying agents, compatible with pravastatin, to impart a desired pH of at least 9 to an aqueous dispersion of said composition.
A method of stabilizing pravastatin for storage, which comprises including with pravastatin one or more basifying agents, compatible with pravastatin, to impart a desired pH of at least 9 to an aqueous dispersion of the pravastatin.
Dependencies are inferred from the claim text.