Liver function improver
AssigneeSuntory Limited
InventorsYoshifumi Shinmen, Kengo Akimoto, Sumio Asami, Yoshihide Suwa, Yoshinori Kitagawa, Michihiro Sugano, Hideaki Yamada, Sakayu Shimizu
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Abstract
A liver function improver, food, or drink comprising, as an effective ingredient, a dioxabicyclo[3.3.0]octane derivative, such as sesamin, sesaminol episesamin, episesaminol, sesamolin, 2-(3,4-methylene dioxyphenyl)-6-(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane, 2,6-bis-(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane or 2- (3,4-methylenedioxyphenyl)-6-(3-methoxy-4-hydroxyphenoxy)-3,7-dioxabicyclo [3.3.0]octane.
Claims3
A pharmaceutical composition of matter for the prevention or treatment of fatty liver or liver disorders, or to decrease glutamic-oxaloacetic aminotransferase, glutamic-pyruvic aminotransferase, serum total cholesterol, serum triglyceride, serum total bilirubin or neutral fat in a mammalian organism, said composition comprising an effective amount of a dioxabicyclo[3.3.0]octane derivative of the formula (I):
- ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 R.sup.5 and R.sup.6 independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, or R.sup.1 and R.sup.2 and/or R.sup.4 and R.sup.5 together form a methylene group or an ethylene group, and n, m and l are 0 or 1, to prevent or treat fatty liver or liver disorder, or to decrease glutamic-oxaloacetic aminotransferase, glutamine-pyruvic aminotransferase, serum total cholesterol, serum triglyceride, serum total bilirubin or neutral fat in a mammalian organism, when R.sup.1 and R.sup.2 together and R.sup.4 and R.sup.5 together are not methylene when n, m and l are 0, and a pharmaceutically acceptable carrier therefor.
Dependencies are inferred from the claim text.