Antibacterial antiplaque anticalculus oral composition
AssigneeColgate-Palmolive Company
InventorsAbdul Gaffar, Nuran Nabi, John Afflitto, Orum Stringer
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Abstract
An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncationic antibacterial agent such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Triclosan). Antiplaque effectiveness is optimized by the presence of an antibacterial-enhancing agent which enhances delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
Claims26
In a method of preparing an oral composition wherein delivery and retention of a plaque-inhibiting antibacterial agent is enhanced by attaching, adhering or bonding to oral surfaces comprising an orally acceptable aqueous vehicle, an effective amount in the range of about 0.01-5% by weight of substantially water insoluble noncationic antibacterial agent and polyphosphate anticalculus amount in an effective anticalculus amount present as a mixture of potassium and sodium salts, the improvement comprising employing potassium and sodium in said composition in a ratio of up to less than 1:1 and employing about 0.5-5% by weight of a water-soluble or swellable antibacterial-enhancing agent which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing group, which said delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces.
In a method of attaching, adhering or bonding a plaque-inhibiting antibacterial agent to oral tooth and gum surfaces which comprises applying on oral surfaces an oral composition comprising an orally acceptable aqueous vehicle, an effective amount in the range of about 0.01-5% by weight of substantially water insoluble noncationic antibacterial agent and polyphosphate anticalculus amount in an effective anticalculus amount present as a mixture of potassium and sodium salts, the improvement comprising employing potassium and sodium in said composition in a ratio of up to less than 1:1 and employing about 0.05-4% by weight of a water-soluble or swellable antibacterial-enhancing agent which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing group, wherein said delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces.
In a method of preparing an oral composition wherein delivery and retention of a plaque-inhibiting antibacterial agent is enhanced by attaching adhering or bonding to oral surfaces comprising an orally acceptable aqueous vehicle and an effective amount in the range of about 0.01-5% by weight of substantially water insoluble noncationic antibacterial agent the polyphosphate anticalculus agent about 0.5-4% by weight of a water-soluble or swellable antibacterial-enhancing agent which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing group, wherein said delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces and employing said polyphosphate in an amount wherein the weight ratio of said antibacterial enhancing agent to said polyphosphate ion ranges from about 1:6 to about 2.7:1.
In a method of attaching, adhering or bonding a plaque-inhibiting antibacterial amount of an antibacterial agent comprising applying to oral surfaces an oral composition comprising an orally acceptable aqueous vehicle and an effective amount in the range of about 0.1-5% by weight of substantially water insoluble noncationic antibacterial agent, the improvement comprising employing polyphosphate anticalculus agent, and 0.05-4% by weight of a water-soluble or swellable antibacterial-enhancing agent which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing group, wherein said delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces and wherein said polyphosphate is in an amount wherein the weight ratio of said antibacterial-enhancing agent to said polyphosphate ion ranges from about 1:6 to about 2.7:1.
Dependencies are inferred from the claim text.