Stabilized bis biguanide/anionic active ingredient compositions
AssigneeColgate-Palmolive Company
InventorsThomas G. Polefka, Deborah S. Sanai, Brian S. Jannone
Life of this patent
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Abstract
An oral composition is provided and a method for making the same. The composition comprises a cationic antibacterial agent, an anionic active ingredient and, as a stabilizing agent, a stabilizing quantity of a betaine surfactant.
Claims12
An oral composition consisting essentially of 0.01 to about 5.0% by weight of a plaque reducing cationic bisbiguanide antibacterial agent and an effective quantity of a fluorine-providing anionic agent, the anionic agent being present in an amount sufficient to release from about 0.005 up to 1% by weight fluoride ion, said cationic and anionic agents being stabilized by a precipitation-inhibiting quantity of a betaine surfactant, said betaine surfactant being present in a quantity in which the weight ratio of betaine to bisguanide (BBR) is effective to prevent precipitation and insufficient to decrease the efficacy of the plaque-reducing activity of said cationic bis-guanide antibacterial agent, the BBR ranging from the minimum BBR to a BBR of less than about 8.
A method for preparing an oral composition comprising about 0.1 to about 5.0% by weight of a plaque-reducing quantity of a cationic bis-biguanide antibacterial agent and an effective quantity of anionic agent and a stabilizing precipitation- inhibiting quantity of a betaine surfactant, the betaine surfactant being present in a quantity in which the weight ratio of betaine to bis-biguanide is effective to prevent precipitation and insufficient to decrease the efficacy of the plaque-reducing activity of the cationic bis-biguanide antibacterial agent comprising:
- providing a first part of said composition comprising said quantity of cationic antibacterial agent, said first part being substantially free of said anionic agent;
- combining said first part with a precipitation-inhibiting quantity of a betaine surfactant to form betaine micelles associated with said antibacterial agent;
- providing a second part of said composition comprising said quantity of anionic agent, said second part being substantially free of said cationic antibacterial agent;
- and
- combining said first part containing the associated betaine micelle antibacterial agent with the second part to form the composition
Dependencies are inferred from the claim text.