Process for the production of an aqueous suspension of hydroxylapatite
AssigneeBK Ladenburg GmbH
InventorsFriedrich Wahl, Andrea Maurer-Rothmann, Karl Merkenich
Life of this patent
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Abstract
A process for the production of an aqueous suspension of hydroxylapatite from calcium hydroxide or calcium oxide, and phosphoric acid in which, while stirring, phosphoric acid is slowly added to an aqueous solution or suspension of the calcium compound up to a calcium/phosphorus mole ratio of 10:6, wherein the course of the reaction and the achievement of the end point of the reaction is determined by the conductivity of the solution or suspension. The process results in the production of essentially pure hydroxylapatite, which is useful as, for example, a teeth cleaning agent, a bone-replacement, or as a carrier material for pharmaceutical compositions.
Claims19
A process for the production of an aqueous suspension of hydroxylapatite comprising the steps of:
- a) forming in a vessel, an aqueous solution or aqueous suspension of a calcium compound selected from the group consisting of calcium hydroxide and calcium oxide,
- b) admixing and reacting phosphoric acid with said solution or suspension so as to form a second solution or suspension of hydroxylapatite, said second solution having a calcium/phosphorus mole ratio of up to about 10:6;
- measuring the conductivity of said second solution or suspension of hydroxylapatite at least periodically during the reaction so as to determine the progress of the reaction and the completion of the reaction, and ending the admixing of the phosphoric acid when the conductivity of the reacting solution has decreased to less than about 10% of the initial value of the conductivity before the addition of the phosphoric acid.
Dependencies are inferred from the claim text.