Process for preparing d-2-(6-methoxy-2-naphthyl)-propionic acid and intermediate thereof

Abstract

A process for the prepaation of d-2-(6-methoxy-2-naphthyl)-propionic acid of formula (I) used as nonsteroid antipyretic analgesics, which comprises reacting oxazolidinone of formula (II) with 6-methoxy-2-naphthylacetchloride of formula (IV), methylizing [N-(y-methoxy-2-naphthyl)acetyl]-oxazolidinone of formula (N), and reacting[N-(2S)-2-(6-methoxy-2-naphthyl)-propionyl]-oxazolidinone of formula (VI) in alkali metal hydroxy, and intermediate compound obtained by the process, [N-(6-methoxy-2-naphthyl)acetyl]-oxazolidinone of formula (V) and [N-(2S)-2-(6-methoxy-2-naphthyl)-propionyl]-oxazolidinone (VI) ##STR1## wherein R.sup.1 is methyl, isopropyl, secondary-butyl, tert-butyl, benzyl, or phenyl group, and R.sup.2 is hydrogen or phenyl group.

Dependencies are inferred from the claim text.