US 5,179,204 A · N-substituted-4-pyrimidinamines and pyrimidinediamines

Abstract

This invention relates to N-heteroaryl-4-pyrimidinamines of the formula ##STR1## where R.sub.1 is hydrogen, loweralkyl, aryl, or arylloweralkyl; R.sub.2 and R.sub.3 are independently hydrogen or loweralkyl, or R.sub.2 and R.sub.3 taken together are aryl; R.sub.4 and R.sub.5 are independently hydrogen or loweralkyl, or R.sub.4 and R.sub.5 taken together are aryl; X is hydrogen, halogen, cyano, nitro, amino, loweralkyl, loweralkoxy, trifluoromethyl or ##STR2## where Y is hydrogen, halogen or loweralkyl; m is an integer of 1 to 3; and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometrical and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as memory enhancing agents and as analgesic agents.

Claims2

Dependent claims

A method of synthesizing a compound of the formula ##STR10## where R.sub.1 is hydrogen, loweralkyl, aryl, or arylloweralkyl;

R.sub.2 and R.sub.3 are independently hydrogen or loweralkyl, or R.sub.2 and R.sub.3 taken together are aryl;
R.sub.4 and R.sub.5 are independently hydrogen or loweralkyl, or R.sub.4 and R.sub.5 taken together are aryl;
X is hydrogen, halogen, cyano, nitro, amino, loweralkyl, loweralkoxy, trifluoromethyl or ##STR11## where Y is hydrogen, halogen or loweralkyl;
m is an integer of 1 to 3;
and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometrical and optical isomers and racemic mixtures thereof which comprises reacting a ##STR12## where Hal is halogen with a compound of the formula ##STR13## where R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as previously defined in a loweralkanol solvent or 1-methyl-2-pyrrolidinone.

2 more elements

Dependencies are inferred from the claim text.

N-substituted-4-pyrimidinamines and pyrimidinediamines

Life of this patent

N-substituted-4-pyrimidinamines and pyrimidinediamines

Life of this patent

Abstract

Claims2