Secretory component-containing composition
AssigneeSnow Brand Milk Products Co., Ltd.
InventorsToshiaki Uchida, Kaoru Sato, Sunichi Dosako, Chouemon Kanno, Norihiro Azuma, Hitoshi Kuriki
Life of this patent
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Abstract
A secretory component-containing composition which is obtainable by contacting a milk or a whey with a cation exchange resin to allow the resin to absorb a secretory component contained in the milk or the whey and then eluting the secretory component and which has the following properties: (a) contains a secretory component with the purity of at least 20% by weight, (b) contains, besides the secretory component, at least an immunoglobulin and/or a serum albumin, and (c) has anti-infectious effects.
Claims9
A production process of a secretory component-containing composition which contains a secretory component with a purity of at least 70% and which has anti-infectious effects, comprising the steps of:
- (a) subjecting a milk or whey to chromatography to remove lactoferrin and lactoperoxidase therefrom;
- (b) desalting the resultant milk or whey so as to give a conductivity of up to 5 mS/cm;
- (c) treating the desalted milk or whey with a cation exchange resin to allow the resin to adsorb a secretory component contained in the milk or whey;
- and
- (d) eluting the secretory component adsorbed by the resin using a salt solution having an ionic strength of 0.005 to 0.25 and a pH of 6 to 9, so that the secretory component can be recovered from the eluate at a purity of 70% or more.
A production process of a secretory component-containing composition which contains a secretory component with a purity of at least 80% and which has anti-infectious effects, comprising the steps of:
- (a) subjecting a milk or whey to chromatography to remove lactoferrin and lactoperoxidase therefrom;
- (b) desalting the resultant milk or whey so as to give a conductivity of up to 5 mS/cm;
- (c) treating the desalted milk or whey with a cation exchange resin to allow the resin to adsorb a secretory component contained in the milk or whey;
- and
- (d) eluting the secretory component adsorbed by the resin using a salt solution having an ionic strength of 0.005 to 0.25 and a pH of 6 to 9;
- (e) desalting the eluate so as t give a conductivity of up to 3 mS/cm;
- and
- (f) passing the desalted eluate through an anion exchange resin, so that the secretory component can be recovered from the passed eluate at a purity of 80% or more.
Dependencies are inferred from the claim text.