Supramolecular surfactants: amphiphilic polymers designed to disrupt lipid membranes
OwnerSteven L. Regeninventor
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Abstract
An amphiphilic polymer, having the monomer unit structure A, B, C, or D: ##STR1## wherein R is at least one H and C.sub.1-6 alkyl, k=1-4, m=4-30, n=2-50 and x=2-500. ##STR2## wherein p and q are, independently, 0-22, and the sum of p and q is 4-22; ##STR3## wherein r and s are, independently, 0-22, and the sum of r and s is in the range 2-44, Ar is a divalent aromatic radical; and compounds in which the ester group in compounds A, B, C and D is replaced by an amide, urea, urethane, ether or carbonate. These compounds are useful for disrupting lipid membranes, as surfactants and dispersing agents and in the treatment of viral, bacterial and fungal diseases.
Claims8
An amphiphilic polymer, consisting of the monomer unit structure:
- ##STR14## wherein R is at least one of H and C.sub.1-6 alkyl, k=1-4, n=2-50, x=2-500, p and q are, independently, 0-22, and the sum of p and q is 4-44;
- and compounds in which the ester group in said polymer is replaced by an amide, urea, urethane, ether or carbonate group.
An amphiphilic polymer, consisting of a monomer unit structure selected from the group consisting of:
- ##STR15## wherein R is at least of H and C.sub.1-6 alkyl, k=1-4, m=4-30, n=2-50, x=2-500, p and q are, independently, 0-22, and the sum of p and q is 4-44, r and s are, independently, 0-22, and the sum of r and s is in the range of 2-44, and Ar is a divalent aromatic radical.
Dependencies are inferred from the claim text.