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US 5,179,123 AGranted
LTB4 synthesis inhibitors
AssigneeG. D. Searle & Co.
InventorsStevan W. Djuric, Richard A. Haack, Julie M. Miyashiro
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Abstract
This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxgen, sulfur, --CH.dbd.CH--or --CH.dbd.N--; wherein R.sub.1 is alkyl, alkenyl or alkynyl of about 1 to 20 carbon atoms; wherein R is --CO.sub.2 R.sup.2, tetrazole, methylsulfonamide or benzenesulfonamide, wherein R.sup.2 is hydrogen, alkyl of 1 to 6 carbon atoms or a pharmaceutically acceptable cation and R.sup.3 is hydroxyl or halogen, having utility as LTB.sub.4 synthesis inhibitors.
Claims10
A compound of the formula:
- ##STR48## or a pharmaceutically acceptable salt thereof wherein X is oxygen;
- wherein Y when present is hydrogen or halogen;
- wherein R.sup.1 is alkyl of 1 to 20 carbon atoms, alkenyl of 2 to 20 carbon atoms, or alkynyl of 2 to 20 carbon atoms;
- wherein R is --CO.sub.2 R.sup.2, tetrazole, methylsulfonamide or benzenesulfonamide;
- wherein R.sup.2 is hydrogen, alkyl of 1 to 6 carbons or a pharmaceutically acceptable cation;
- and
- wherein R.sup.3 is hydroxyl or halogen.
4 more elements
Dependencies are inferred from the claim text.