Treatment of central nervous disorders with imidazole compounds

A method of treating impaired cognitive performance which comprises administering to a mammal in need of such treatment an effective amount of a compound having the formula (II):

• ##STR10## wherein Q and Q.sup.1 -Q.sup.6, are independently selected from hydrogen and alkyl of 1-4 carbon atoms;
• P is a carbonyl group or ##STR11## with N and O, respectively, bonded to Ar;
• B is an alkyl group of 1 to 6 carbon atoms;
• Any of the --(CH.sub.2).sub.c -- groups independently are optionally substituted by one or two alkyl groups of 1 to 4 carbon atoms;
• Ar is a benzene ring or a naphthyl or indolyl ring system any of which is optionally substituted in any position by one or more substituents independently selected from alkyl groups of 1 to 4 carbon atoms being optionally substituted by one or more halogen atoms, alkoxy of 1 to 9 carbon atoms, halogen, nitro, amino, carboxy, alkoxycarbonyl of 1 to 4 carbon atoms, and hydroxy;
• R.sup.2 is H, Cl, Br, or I, alkyl of 1 to 4 carbon atoms, perfluoroalkyl of 1 to 3 carbon atoms, phenyl or COR.sup.16 ;
• R.sup.3 is alkyl, alkenyl or alkynyl of 3 to 7 carbon atoms;
• R.sup.5 is H, Cl, Br, I, or F, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms;
• R.sup.6 is --CO.sub.2 H, NHSO.sub.2 CF.sub.3 or ##STR12## R.sup.16 is H;
• alkyl of 1 to 6 carbon atoms;
• phenyl;
• phenylalkyl where alkyl is 1 to 6 carbon atoms;
• OH;
• alkoxy of 1 to 6 carbon atoms;
• phenoxy;
• benzyloxy;
• NH.sub.2 ;
• alkylamino or dialkylamino where alkyl is 1 to 6 carbon atoms;
• or morpholino;
• and pharmaceutically acceptable salts thereof.