Substituted N-(quinolin-2-yl-methoxy) benzyl-sulphonylurea leukotriene synthesis inhibitors
AssigneeBayer Aktiengesellschaft
InventorsKlaus Mohrs, Siegfried Raddatz, Romanis Fruchtmann, Christian Kohlsdorfer, Reiner Muller-Peddinghaus, Pia Theisen-Popp
Life of this patent
Estimating the term…
Abstract
Inhibiting leucotriene synthesis in patients with novel substituted N-(quinolin-2-yl-methoxy)benzylsulphonyl-urea of the formula ##STR1## in which A, B, D, E, G, K and M each independently is H, OH, halogen, CF.sub.3, OCF.sub.3, COOH, alkyl, alkoxy, alkoxycarbonyl or aryl, R.sup.1 is alkyl or cycloalkyl, R.sup.2 and R.sup.3 each independently is H or alkyl, and R.sup.4 is alkyl, aryl or a heterocyclic radical, and salts thereof.
Claims9
A substituted N-(quinolin-2-yl-methoxy)benzyl-sulphonylurea of the formula ##STR15## in which A, J, D, E, G, Z and M are identical or different and
- represent hydrogen, hydroxyl, halogen, trifluoromethyl, trifluoromethoxy or carboxyl,
- represent straight-chain or branched alkyl having up to 10 carbon atoms, which is optionally substituted by hydroxyl or halogen,
- represent straight-chain or branched alkoxy or alkoxycarbonyl having up to 10 carbon atoms, or
- represent aryl having 6 to 10 carbon atoms, which is optionally substituted by halogen, nitro, cyano or by straight-chain or branched alkyl or alkoxy having up to 8 carbon atoms,
- R.sup.1 represents straight-chain or branched alkyl having up to 10 carbon atoms, which is optionally substituted by alkoxy having up to 8 carbon atoms, halogen or cycloalkyl having 3 to 8 carbon atoms, or
- represents cycloalkyl having 3 to 8 carbon atoms, which is optionally substituted by halogen or straight-chain or branched alkyl having up to 8 carbon atoms,
- R.sup.2 and R.sup.3 are identical or different and
- represent hydrogen or straight-chain or branched alkyl having up to 10 carbon atoms, which is optionally substituted by halogen, hydroxyl or by aryl having 6 to 10 carbon atoms, and
- R.sup.4 represents straight-chain or branched alkyl, having up to 8 carbon atoms, which is optionally substituted by fluorine, chlorine, nitro, cyano, hydroxyl, or by aryl having 6 to 10 carbon atoms, or phenyl,
- or represents phenyl which is optionally substituted by up to 2 identical or different substituents from the group consisting of fluorine, chlorine, bromine, nitro, cyano, hydroxyl, straight-chain or branched alkyl, alkylthio and alkoxy having up to 6 carbon atoms, trifluoromethyl and trifluoromethoxy,
- or a salt thereof.
Dependencies are inferred from the claim text.