Salts of non-steroidal anti-inflammatory carboxylic acids and anti-lipidemic carboxylic acids
OwnerIsaac A. Angresinventor
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Abstract
Novel choline salts of non-steroidal anti-inflammatory carboxylic acids and anti-lipidemic carboxylic acids are described. Additionally, blends of choline salts with the above carboxylic acids are also described. The new salts and compositions offer new therapeutic advantages.
Claims20
A compound of the formula:
- ##STR3## wherein ##STR4## is a non-steroidal anti-inflammatory carboxylic acid selected from the group comprising the arylacetic acids, the arylpropionic acids, the fenamic acids, the biphenyl carboxylic acids and the diphenylether carboxylic acids.
A compound of the formula ##STR5## wherein ##STR6## is a carboxylic acid having anti-hyper lipoproteinenic activity selected from the group comprising clofibric acid, gemfibrozil, 5, 8, 11, 14, 17 - eicosapentaenoic acid, oxiniacic acid, and nicotinic acid.
A pharmaceutical composition having less stomach irritation comprising:
- choline or its acceptable pharmaceutical salt;
- a non steroidal anti-inflammatory carboxylic acid selected from the group comprising the arylacetic acids, the aryl propionic acids, the fenamic acids, the biphenylcarbodylic acids and a pharmaceutical inert carrier.
A pharmaceutical composition suitable for reducing cholesterol levels comprising:
- choline or its acceptable pharmaceutical salt;
- an anti-hyperlipidemic carboxylic acid selected from the group of clofibric acid, gemfibrozil, clinofibrate, bezafibrate ciprofibrate, xenbucin, acipimox, acifran, 5, 8, 11, 14, 17 eicosapentaenoicacid, oxiniacic acid and nicotinic acid and a pharmacetical acceptable carrier.
Dependencies are inferred from the claim text.