Antiviral phosphoric acid esters of oxetanocins
AssigneeNippon Kayaku Kabushiki Kaisha
InventorsSeiichi Saito, Shigeru Hasegawa, Masayuki Kitagawa, Nobuyoshi Shimada, Katsutoshi Takahashi, Jun-ichi Seki, Hiroo Hoshino, Yukihiro Nishiyama, Kenichi Matsubara, Takemitsu Nagahata
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Abstract
The present invention relates to phosphoric acid esters of oxetanocins having an antiviral activity which are represented by general formula (I): ##STR1## wherein R.sub.1 represents a phosphoric acid ester residue, X represents hydrogen, hydroxy or hydroxymethyl group, and B represents a purine base residue, and pharmacologically acceptable salts thereof.
Claims4
A phosphoric acid ester of oxetanocins represented by formula (I):
- ##STR38## wherein R.sub.1 represents ##STR39## X represents hydrogen, hydroxy or hydroxymethyl, and B represents an adenine moiety, and pharmacologically acceptable salts thereof.
A phosphoric acid ester of oxetanocin A and 2'-dehydroxymethyloxetanocin A represented by the following formula:
- ##STR40## wherein X represents hydrogen or hydroxymethyl group, and pharmacologically acceptable salts thereof.
An antiviral composition comprising as an effective component a phosphoric acid ester of oxetanocins represented by formula (I):
- ##STR41## wherein R.sub.1 represents ##STR42## X represents hydrogen or hydroxymethyl, and B represents an adenine moiety, and pharmacologically acceptable salts thereof.
Dependencies are inferred from the claim text.