Method for blocking platelet adhesion to collagen
AssigneeMerck & Co., Inc.
InventorsThomas M. Connolly, Jerzy Karczewski
Life of this patent
Estimating the term…
Abstract
A method for blocking platelet adhesion to collagen by contacting platelets with a polypeptide having one of the following sequences: NH.sub.2 (Ch) Ala Arg Gly Asp (Cx) COOH (i) NH.sub.2 (Ch) Ala Ala Gly Asp (Cx) COOH (ii) NH.sub.2 (Ch) Ala Arg Tyr Asp (CX) COOH (iii) NH.sub.2 (Ch) Ala Arg Gly Asp (Cy) Z (iv) wherein Ch, Cx, Cy are defined amino acid sequences or conservatively substituted amino acid sequences, and Z is NH.sub.2 or COOH.
Claims3
A method for inhibiting collagen-stimulated platelet activation which comprises blocking platelet adhesion to collagen by contacting a polypeptide having the following sequence:
- NH.sub.2 (Ch) Ala Ala Gly Asp (Cx) COOH Seq. ID No. 2
- NH.sub.2 (Ch) Ala Arg Gly Asp (Cy) Z Seq. ID No. 5.
- wherein
- Ch is ##STR8## or conservative amino acid substitutions thereof;
- Cx is ##STR9## or conservative amino acid substitutions thereof;
- Cy is ##STR10## or conservative amino acid substitutions thereof;
- and Z is NH.sub.2 or COOH;
- with platelets, in the presence of collagen.
A method for inhibiting collagen-stimulated platelet activation in a mammal which comprises blocking platelet adhesion to collagen by contacting a polypeptide having the following sequence:
- NH.sub.2 (Ch) Ala Ala Gly Asp (Cx) COOH Seq. ID No. 2
- NH.sub.2 (Ch) Ala Arg Gly Asp (Cy) Z Seq. ID No. 5
- wherein
- Ch is ##STR11## or conservative amino acid substitutions thereof;
- Cx is ##STR12## or conservative amino acid substitutions thereof;
- Cy is ##STR13## or conservative amino acid substitutions thereof;
- and Z is NH.sub.2 or COOH;
- with platelets.
A composition for inhibiting collagen-stimulated platelet activation in a mammal by blocking platelet adhesion to collagen, which comprises a polypeptide having the following sequence;
- NH.sub.2 (Ch) Ala Ala Gly Asp (Cx) COOH Seq. ID No. 2
- NH.sub.2 (Ch) Ala Arg Gly Asp (Cy) Z Seq. ID No. 5
- wherein
- Ch is ##STR14## or conservative amino acid substitutions thereof;
- Cx is ##STR15## or conservative amino acid substitutions thereof;
- Cy is ##STR16## or conservative amino acid substitutions thereof;
- and Z is NH.sub.2 or COOH.
Dependencies are inferred from the claim text.