Method of treatment using an anticoagulant polypeptide
AssigneeKowa Company, Ltd.
InventorsAkio Iwasaki, Makoto Suda, Yushi Saino
Life of this patent
Estimating the term…
Abstract
A polypeptide having an amino acid sequence as shown in FIG. 1 and its preparation method are disclosed. A DNA fragment capable of coding CPBII polypeptide (human placenta-derived coagulation inhibitor) is first obtained from the human placental cDNA library by using a CPBII-specific antibody as a probe. Then, microorganism cells are transformed by the use of a recombinant plasmid incorporated with the DNA fragment, allowing the resultant transformant to express the CPBII gene, to finally obtain a CPBII-like polypeptide. The polypeptide of this invention exhibits strong anticoagulation activities, and useful for an active component of anticoagulation medicines and preventin in vivo blood coagulation.
Claims7
A process for preventing coagulation of blood, which comprises administering to a subject in need thereof, an effective amount of anti-coagulant comprising as an active component, a substantially pure polypeptide consisting essentially of the amino acid sequence shown in FIG. 1.
Dependencies are inferred from the claim text.