Lyophilized and reconstituted red blood cell compositions
AssigneeCryopharm Corporation
InventorsRaymond P. Goodrich, Christine M. Williams, Roger W. Hackett
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Abstract
A process and medium are disclosed for the lyophilization of red blood cells which comprises the use of solutions including monosaccharide hexoses and pentoses, and biocompatible amphipathic polymers to permit the reconstitution of viable red blood cells. Also disclosed are lyophilized and reconstituted erythrocyte and hemosome containing compositions.
Claims21
A transfusably-useful erythrocyte-containing and/or hemosome-containing composition reconstituted after lyophilization characterized by a P.sub.50 in the range of about 26-28, an oxyhemoglobin content greater than about 90% of that of normal red blood cells, morphology,and normal ATP metabolism.
A lyophilized erythrocyte-containing and/or hemosome-containing composition characterized by a phosphorous-31 NMR lineshape characteristic of a bilayer in a gel phase.
Dependencies are inferred from the claim text.