Liquid suspensions of nitrofurantoin
AssigneeNorwich Eaton Pharmaceuticals, Inc.
InventorsVijay Shahi, Margaret A. McGowan, Michael J. Kane
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Abstract
Compositions, for the administration of nitrofurantoin to a human or other animal subject, comprising: (a) a safe and effective amount of nitrofurantoin particulates having a surface consisting of nitrofurantoin monohydrate, wherein said particulates have a mean particle size greater than about 200 mesh size; (b) nitrofurantoin monohydrate; (c) an effective amount of a suspending agent; and (d) water; wherein the pH of said composition is from about 1 to about 6; and said nitrofurantoin monohydrate is dissolved in said water at saturation level. The nitrofurantoin of this invention are highly efficacious for the oral delivery of nitrofurantoin.
Claims11
A pharmaceutical suspension, for the administration of nitrofurantoin to a human or other animal subject, comprising:
- (a) from about 0.1% to about 3.5% of nitrofurantoin particulates having a surface consisting of nitrofurantoin monohydrate, wherein said particulates have a mean particle size greater than about 200 mesh size;
- (b) from about 0.010% to about 0.027% of nitrofurantoin monohydrate;
- (c) an effective amount of a suspending agent;
- and
- (d) water;
- wherein the pH of said composition is from about 1 to about 6;
- and said nitrofurantoin monohydrate is dissolved in said water at saturation level.
A composition, for the administration of nitrofurantoin to a human or other animal subject, comprising:
- (a) from about 0.1% to about 3.5% of nitrofurantoin particulates having a surface consisting of nitrofurantoin monohydrate, wherein said particulates have a mean particle size distribution of from about 30 mesh to about 100 mesh and a BET surface area of at least about 0.2 M.sup.2 /g;
- (b) nitrofurantoin monohydrate;
- (c) methyl cellulose at a level of from about 0.1% to about 10%;
- (d) magnesium aluminum silicate a level of from about 0.2% to about 10%;
- and
- (e) water;
- wherein the pH of said composition is from about 3 to about 5.5;
- and said nitrofurantoin monohydrate is dissolved in said water at saturation level.
Dependencies are inferred from the claim text.