Dosage form
AssigneeKabi Pharmacia Aktiebolaq
InventorsKarin Malmqvist-Granlund, Christer Hermansson, Soren Kulstad
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Abstract
The invention relates to an oral pharmaceutical multiple units formulation made up of individual cores containing a pharmacologically active substance, the cores being provided with a coating consisting essentially of a polymer that is insoluble in, impermeable to and non-soluble in water and in gastrointestinal fluids, and a water-soluble pore-creating substance, which is randomly distributed in said polymer, whereby said coated cores form units providing an essential zero order diffusion controlled release rate of said active substance. The invention also comprises a method of preparing these formulations.
Claims8
Oral pharmaceutical multiple units formulation comprising individual cores containing a pharmacological active substance, at least some of said cores being provided with a coating consisting essentially of:
- a) a polymer containing 80-95% weight by weight vinyl chloride, 1-19% weight by weight vinyl acetate, and 0% to 10% weight by weight vinyl alcohol;
- and
- b) a pore-creating substance that is soluble in water and is randomly distributed in said polymer;
- c) whereby said coated cores form units providing an essentially zero-order diffusion controlled release rate of said pharmacological active substance.
Oral pharmaceutical multiple units formulation comprising individual cores containing a pharmacological active substance, at least some of said cores being provided with a coating consisting essentially of:
- a) a terpolymer containing about 92 percent weight by weight vinyl chloride, about 4 percent weight by weight vinyl acetate, and about 4 percent weight by weight vinyl alcohol;
- and
- b) micronized sucrose;
- c) whereby said coated cores form units providing an essentially zero-order diffusion controlled release rate of said pharmacological active substance.
Dependencies are inferred from the claim text.