Chinese herbal extracts in the treatment of HIV related disease in vitro
AssigneeCedars-Sinai Medical Center
InventorsDavid D. Ho, Xiling S. Li
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Abstract
The invention features herbal extracts from ten (10) Chinese Herbal Medicines demonstrating significant in vitro and ex vivo anti-HIV activity and their use for the diagnosis and treatment of HIV and HIV-related disease.
Claims20
A method of inhibiting in vitro HIV infection in human T lymphocyte cells and mononuclear phagocytic lineage cells infected with HIV comprising contacting said infected cells with a pharmaceutical preparation consisting essentially of an extract from Salvia miltiorrhiza, at a concentration of said extract which is effective to inhibit viral antigen expression in said HIV infected cells.
A method of inhibiting in vitro HIV infection in human T lymphocyte cells and mononuclear phagocytic lineage cells infected with HIV comprising contacting said infected cells with a pharmaceutical preparation consisting essentially of an extract from Scutellaria baicaleusis, at a concentration of said extract which is effective to inhibit viral antigen expression in said HIV infected cells.
A method of inhibiting in vitro HIV infection in human T lymphocyte cells and mononuclear phagocytic lineage cells infected with HIV comprising contacting said infected cells with a pharmaceutical preparation consisting essentially of an extract from Coptis chineusis, at a concentration of said extract which is effective to inhibit viral antigen expression in said HIV infected cells.
A method of inhibiting in vitro HIV infection in human T lymphocyte cells and mononuclear phagocytic lineage cells infected with HIV comprising contacting said infected cells with a pharmaceutical preparation consisting essentially of an extract from Ligusticum wallichii, at a concentration of said extract which is effective to inhibit viral antigen expression in said HIV infected cells.
A method of inhibiting in vitro HIV infection in human T lymphocyte cells and mononuclear phagocytic lineage cells infected with HIV comprising contacting said infected cells with a pharmaceutical preparation consisting essentially of an extract from Illicium lanceolatum, at a concentration of said extract which is effective to inhibit viral antigen expression in said HIV infected cells.
A method of inhibiting in vitro HIV infection in human T lymphocyte cells and mononuclear phagocytic lineage cells infected with HIV comprising contacting said infected cells with a pharmaceutical preparation consisting essentially of an extract from Isatis tinctoria, at a concentration of said extract which is effective to inhibit viral antigen expression in said HIV infected cells.
A method of inhibiting in vitro HIV infection in human T lymphocyte cells and mononuclear phagocytic lineage cells infected with HIV comprising contacting said infected cells with a pharmaceutical preparation consisting essentially of an extract from Erycibe obtusifolia, at a concentration of said extract which is effective to inhibit viral antigen expression in said HIV infected cells.
A method of inhibiting in vitro HIV infection in human T lymphocyte cells and mononuclear phagocytic lineage cells infected with HIV comprising contacting said infected cells with a pharmaceutical preparation consisting essentially of an extract from Acanthopanax graciliatylus, at a concentration of said extract which is effective to inhibit viral antigen expression in said HIV infected cells.
A method of inhibiting in vitro HIV infection in human T lymphocyte cells and mononuclear phagocytic lineage cells infected with HIV comprising contacting said infected cells with a pharmaceutical preparation consisting essentially of an extract from Bostaurus domesticus, at a concentration of said extract which is effective to inhibit viral antigen expression in said HIV infected cells.
A method of inhibiting in vitro HIV infection in human T lymphocyte cells and mononuclear phagocytic lineage cells infected with HIV comprising contacting said infected cells with a pharmaceutical preparation consisting essentially of an extract from Inula helenium, at a concentration of said extract which is effective to inhibit viral antigen expression in said HIV infected cells.
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