Adjuvant complexes and vaccine made therefrom
AssigneeCoopers Animal Health Limited
InventorsNeill M. MacKenzie, Angela M. O'Sullivan
Life of this patent
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Abstract
"Iscom" adjuvant matrices, comprising a sterol, a glycoside, a solubilized water-insoluble antigen and, optionally, a phospholipid, may be formed without removing the solubilizing agent used for the antigen. The glycoside is preferably Quil A and the sterol is preferably cholesterol.
Claims18
A vaccine comprising a water insoluble antigen solubilised with a solubilising agent, a glycoside and a sterol which form iscoms, the iscoms being formed without removal of said solubilising agent.
A vaccine prepared by solubilising a water insoluble antigen with a solubilising agent, admixing the solubilised antigen, a glycoside and a sterol and forming iscoms without removal of the solubilising agent.
A process for making an iscom matrix, the process comprising admixing a glycoside, a sterol and a solubilising agent and forming an iscom matrix without removal of the solubilising agent.
Dependencies are inferred from the claim text.