Vaccine against Lyme disease
AssigneesMax-Planck-Gesellschaft zur Forderung der Wissenschaften e.V., Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
InventorsMarkus M. Simon, Ulrich E. Schaible, Klaus Eichmann, Michael Kramer, Wallich Reinhard
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Abstract
The present invention provides a vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi. The present invention also provides a process for obtaining this vaccine, as well as new monoclonal antibodies and antigens.
Claims7
Vaccine against Lyme disease comprising at least one monoclonal antibody which specifically binds to an antigen selected from the group consisting of 31 kd OspA antigen of Borrelia burgdorferi and 34 kd OspB antigen of Borrelia burgdorferi said molecular weights of 31 kd and 34 kd determined by SDS PAGE, wherein said monoclonal antibody is characterized by conferring protection against Lyme disease in a subject to which it is administered, wherein said monoclonal antibody which specifically binds to 31 kd OspA antigen is selected from the group consisting of (a) monoclonal antibody of isotype IgG2b which specifically binds to an epitope bound by monoclonal antibody produced by hybridoma cell line ECACC89091302 and (b) monoclonal antibody of isotype IgG1 which specifically binds to an epitope bound by monoclonal antibody produced by hybridoma cell line ECACC90050406, and said monoclonal antibody which specifically binds to 34 kd OspB antigen is selected from the group consisting of (c) monoclonal antibody of isotype IgG2b which specifically binds to an epitope bound by monoclonal antibody produced by hybridoma cell line ECACC90050405 and (d) monoclonal antibody of isotype IgG1 which specifically binds to an epitope bound by monoclonal antibody produced by hybridoma cell line ECACC90050407.
Method for treating a condition caused by Borrelia burgdoferi infection and selected from the group consisting of arthritis, carditis, and hepatitis comprising administering to an animal infected with Borrelia burgdoferi, an amount of the vaccine of claim 55 sufficient to treat onset of said condition.
Dependencies are inferred from the claim text.