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US 5,178,856 AGranted
Enhancing growth of megakaryocytes in mammals using interleukin 6
AssigneeThe Board of Regents of the University of Oklahoma
InventorSamuel A. Burstein
Life of this patent
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Abstract
A therapeutic method for treating mammals by administering an effective dosage of a substance comprising interleukin 6 and interleukin 3 into the mammal for enhancing the growth of megakaryocytes and platelets.
Claims13
A method to enhance the growth of and production of platelets from a megakaryocyte in vitro, comprising:
- exposing the megakaryocyte in vitro to an effective amount of a substance comprising interleukin 6.
A method of in vitro treatment of both a megakaryocyte progenitor and a megakaryocyte, wherein such treatment increases megakaryocyte numbers and promotes megakaryocyte growth, comprising:
- exposing both the megakaryocyte progenitor and the megakaryocyte in vitro to an effective amount of a substance comprising interleukin 3 and interleukin 6.
A method of treating both a megakaryocyte progenitor and a megakaryocyte in vitro, comprising:
- exposing both the megakaryocyte progenitor and the megakaryocyte in vitro to an effective amount of a substance comprising interleukin 6, wherein said substance acts in vitro to increase megakaryocyte numbers, promote megakaryocyte growth, and enhance the differentiation of the megakaryocyte into a plateletproducing cell.
Dependencies are inferred from the claim text.