Proccess for the manufacture of 2-alkoxymethylacrolein
AssigneeAmerican Cyanamid Company
InventorHenry L. Strong
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Abstract
There is provided a process for the manufacture of 2-alkoxymethylacrolein compounds via the reaction of an appropriate alcohol and acrolein in the presence of an acid and a trisubstituted amine to form an intermediate and the subsequent reaction of the intermediate with formaldehyde in the presence of an acid and a disubstituted amine.
Claims20
A process for the manufacture of a compound of formula I ##STR8## wherein R is C.sub.1 to C.sub.6 alkyl, which comprises reacting ROH wherein R is C.sub.1 to C.sub.6 alkyl with at least one molar equivalent of acrolein in the presence of a mineral acid, a catalytic amount of trisubstituted amine of the formula N(R.sub.2).sub.3, wherein R.sub.2 is C.sub.1 to C.sub.4 alkyl or C.sub.1 to C.sub.4 alkanol, a solvent, wherein the solvent is water or a mixture of water and a water-miscible organic solvent, to form an intermediate and reacting said intermediate with at least one molar equivalent of formaldehyde in the presence of a mineral acid, a catalytic amount of a disubstituted amine of the formula NH(R.sub.3).sub.2, wherein R.sub.3 is C.sub.1 to C.sub.6 alkyl, and a solvent, wherein the solvent is water or a mixture of water and a water-miscible organic solvent, to form the formula I compound.
A process for the manufacture of compound of formula I ##STR9## wherein R is C.sub.1 to C.sub.6 alkyl which comprises reacting a compound of formula II ##STR10## wherein R is C.sub.1 to C.sub.6 alkyl and W is CHO or CH(OR.sub.1).sub.2 and R.sub.1 is C.sub.1 to C.sub.4 alkyl, with at least one molar equivalent of formaldehyde in the presence of a mineral acid, a catalytic amount of a disubstituted amine of the formula NH(R.sub.3).sub.2, wherein R.sub.3 is C.sub.1 to C.sub.6 alkyl, and a solvent, wherein the solvent is water or a mixture of water and a water-miscible organic solvent.
Dependencies are inferred from the claim text.