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US 5,177,230 AGranted
Chiral phospholane transistor metal catalysts
AssigneeE. I. Du Pont de Nemours and Company
InventorMark J. Burk
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Abstract
Chiral 2,5-disubstituted phospholanes useful as transition metal ligands in asymmetric catalysis and processes for their preparation are disclosed.
Claims14
A compound represented by the following formula II comprising:
- ##STR7## wherein:
- R is a lower alkyl, trifluoromethyl, phenyl, substituted phenyl, aralkyl or ring-substituted aralkyl;
- A is CCH.sub.3, CH, N, or P;
- and
- n is an integer having a value of from 1 to 12.
2 more elements
A process for the preparation of a compound of formula II ##STR8## wherein:
- R is a lower alkyl, trifluoromethyl, phenyl, substituted phenyl, aralkyl or ring-substituted aralkyl;
- n is an integer having a value of from 1 to 12;
- and
- A is CCH.sub.3, CH, N or P;
- comprising reacting a phenyl substituted phospholane of formula III ##STR9## wherein R is as defined in formula II, with lithium and a trihalo compound of formula
- A[(CH.sub.2).sub.n X].sub.3
- wherein X is halogen and A is as defined in formula II, to yield the desired compound of formula II.
4 more elements
Dependencies are inferred from the claim text.