N-phenyl-N'-thienylmethyl-bis-diamino-5-methylene-1,3-dioxane-4,6-dione compounds
AssigneeAmerican Home Products Corporation
InventorsWilliam F. Fobare, Donald P. Strike
Life of this patent
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Abstract
The compounds of the formula: ##STR1## wherein X, Y and Z are, independently, hydrogen, halogen, hydroxy, nitro, cyano, carboxyl, trifluoromethyl, phenyl, amino, mono and dialkylamino, C.sub.1 -C.sub.12 alkyl or C.sub.1 -C.sub.12 alkoxy; R.sup.1 represents hydrogen, C.sub.1 -C.sub.18 saturated or unsaturated alkyl, cycloalkyl, phenyl, benzyl or substituted phenyl or substituted benzyl where the substituents are C.sub.1 -C.sub.12 alkyl, or C.sub.1 -C.sub.12 alkoxy; R.sup.2 represents a substituted thienyl group where the substituents are, independently, the same as X, Y and Z; or a pharmaceutically acceptable salt thereof, are ACAT inhibitors.
Claims7
A compound of the formula:
- ##STR5## wherein X,Y and Z are, independently, hydrogen, halogen, hydroxy, nitro, cyano, carboxyl, trifluoromethyl, phenyl, amino, mono and dialkylamino in which the alkyl groups have 1 to 6 carbon atoms, C.sub.1 -C.sub.12 alkyl or C.sub.1-C.sub.12 alkoxy;
- R.sup.1 represents hydrogen, C.sub.1 -C.sub.18 saturated alkyl, C.sub.2 -C.sub.18 unsaturated alkyl, cycloalkyl of 5 to 7 carbon atoms, phenyl, benzyl or substituted phenyl or substituted benzyl where the substituents are C.sub.1 -C.sub.12 alkyl, or C.sub.1 -C.sub.12 alkoxy;
- R.sup.2 represents a substituted thienyl group where the substituents are, independently, the same as X, Y and Z;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.