Back to results
US 5,177,215 AGranted
Heterocyclic compounds and pharmaceutical use thereof
AssigneeYamanouchi Pharmaceutical Co., Ltd.
InventorsKiyoshi Murase, Toshiyasu Mase, Hiromu Hara, Kenichi Tomioka
Life of this patent
Estimating the term…
Abstract
Novel heterocyclic compounds shown by the general formula ##STR1## or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of anaphylaxis (SRS-A).
Claims7
A heterocyclic compound represented by the following formula (I) ##STR98## or a pharmaceutically acceptable salt thereof;
- wherein R.sup.1 represents an alkanoyl group;
- R.sup.2 represents a C.sub.1 -C.sub.6 alkyl group;
- A represents a lower C.sub.1 -C.sub.6 alkylene group;
- Y represents an oxygen atom or a sulfur atom;
- .circle.Het represents one ring selected from the group consisting of, a benzimidazole ring, a 1H-1,2,3-triazole ring, a 1H-1,2,4-triazole ring, a 2H-pyran ring and a 4H-pyran ring;
- R.sup.3, R.sup.4, R.sup.5, which may be the same or different, each represents a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a group shown by the formula --A.sup.1 --R.sup.6 (wherein A.sup.1 represents a C.sub.1 -C.sub.6 alkylene group and R6 represents a hydroxy group), a hydroxy group, an oxo group, an amino group, a group shown by the formula --NH--CO--R.sup.9 (wherein R.sup.9 represents a carboxy-C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.6 alkoxycarbonyl C.sub.1 -C.sub.6 alkyl group) or a carboxy group;
- however, when .circle.Het is a heterocyclic ring fused with a benzene ring, Y is bonded to the heterocyclic ring.
4 more elements
Dependencies are inferred from the claim text.