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AssigneeVyzkumng, USTAV pro farmacii a biochemii, Statni podnik
InventorsMiroslav Kuchar, Marie Poppova, Jaroslava Grimova, Eva Maturova
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This relates to substances represented by formula (I), wherein X stands for represented by either OR in which R is an alkyl of 1 to 4 carbon atoms, or NHR in which is an alkyl of 1 to 4 carbon atoms, or a (CH.sub.2).sub.n NR.sub.2 group wherein n is 2 or 3 while R.sup. is an methyl or an ethyl group; eventually X may represent morpholinyl. Also considered are salts of 4-(2,4-difluorbiphenylyl)-2-methyl-4-oxobutanoic acid with appropriate inorganic or organic bases represented by formula (II) wherein B.sup.+ is either an alkaline metal cation, alkaline earth metal cation, cyclohexylamine cation, or lysine cation. Said substances are characterized by antiinflamatory properties comparable to (and greater than) the initial acid while simultaneously said modifications of their physico-chemical properties broaden the posibilities of their therapeutic application. ##STR1##
Derivative compounds of 4-(2,4-difluorobiphenylyl)-2-methyl-4-oxobutanoic acid, selected from the group consisting of compounds of the formula ##STR4## wherein X is OR in which R is an alkyl group of 1 to 4 carbon atoms, NHR in which R is an alkyl group of 1 to 4 carbon atoms, (CH.sub.2).sub.n NR'.sub.2 in which n is 2 or 3 and R' is a methyl or an ethyl group, or morpholinyl;
Derivative compound of 4-(2,4-difluorobiphenylyl)-2-methyl-4-oxobutanoic acid of the formula ##STR6## wherein X is OR in which R is an alkyl group of 1 to 4 carbon atoms, NHR in which R is an alkyl group of 1 to 4 carbon atoms, (CH.sub.2).sub.n NR'.sub.2 in which n is 2 or 3 and R' is a methyl or an ethyl group, or morpholinyl.
Derivative compound of 4-(2,4-difluorobiphenylyl)-2-methyl-4-oxobutanoic acid of the formula ##STR7## wherein B.sup.+ is a cyclohexlamine cation or a lysine cation.
The L-lysine salt of 4-(2,4-difluorobiphenylyl)-2-methyl-4-oxobutanoic acid.
Dependencies are inferred from the claim text.