Aryloxy alkanols as anti-retrovirus agents
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsRoger A. Parker, Sai P. Sunkara
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Abstract
Aryloxyalkanol derivatives having the formula Ar--O(CH.sub.2).sub.n OH wherein n is an integer from 3 to 8 and Ar is (1) 1- or 2-naphthylenyl, (2) phenyl optionally substituted by from 1 to 3 C.sub.1-4 lower alkyl groups, or (3) a diphenyl moiety of structure ##STR1## wherein Y is a bond, CH.sub.2 or CH.sub.2 O, and esters thereof have antiretrovirus activity and are effective in a method for treatment of a retrovirus infection.
Claims4
A method of treating a retroviral infection in a patient in need thereof which comprises administering to said patient an anti-retrovirally effective amount of a compound of the formula:
- Ar--O(CH.sub.2).sub.n OH
- wherein n is an integer from 3 to 8 and Ar is 1- or 2-naphthylenyl, an ester thereof with a C.sub.1-4 alkanoic, alkenoic, alkanedioic or alkenedioic acid having from 1 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.