Dichloro-substituted imidazole derivatives as antifungal agents
AssigneeSociedad Espanola de Especialidades Farmaco-Terapeuticas S.A.
InventorsRomeo A. Rovati, Ricardo C. Mestres
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Abstract
Dichloro-substituted 1-(5H-dibenzo[a,d]cyclohepten-5-yl)-1H-imidazole comnds of formula (I), in which --X-- is either --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, and their pharmaceutically acceptable addition salts, preferably the nitric acid ones. Products of formula (I) are prepared from products of formula (VI) where Z represents a leaving group such as halogen, by treatment with an excess of imidazole in dimethylformamide. Products (I) show an antifungal activity comparable -or superior- to antimycotics in the market, such as Clotrimazole and Bifonazole. ##STR1##
Claims9
Dichloro-substituted 1-(5H-dibenzo[a,d]cyclohepten-5-yl)-1H-imidazole compound of formula (I), where --X-- is either a --CH.sub.2 --CH.sub.2 -- or a --CH.dbd.CH-- group, and pharmaceutically acceptable salts thereof. ##STR9##
Method for treating antifungal infections in humans and animals which comprises administering an antifungal effective amount of 1-(2,4-dichloro-5H-dibenzo[a,d]cyclohepten-5-yl)-1H-imidazole or a pharmaceutical acceptable salt thereof, in combination with a pharmaceutically acceptable excipient or carrier.
Dependencies are inferred from the claim text.