Substituted 5-((tetrazolyl)alkenyl)imidazoles and pharmaceutical methods of use thereof

A compound of the formula:

• ##STR23## in which:
• R.sup.1 is adamantylmethyl, or phenyl, biphenyl, or naphthyl, with each aryl group being unsubstituted or substituted by one to three substituents selected from Cl, Br, F, I, C.sub.1 -C.sub.6 alkyl, nitro, CO.sub.2 R.sup.7, C.sub.1 -C.sub.6 alkoxy, hydroxy, SC.sub.1 -C.sub.6 alkyl, SO.sub.2 C.sub.1 -C.sub.6 alkyl, tetrazol-5-yl, SO.sub.2 NHR.sup.7, NHSO.sub.2 R.sup.7, SO.sub.3 H, PO(OR.sup.7).sub.2, CONR.sup.7 R.sup.7, CN, NR.sup.7 R.sup.7, NR.sup.7 COH, NR.sup.7 COC.sub.1 -C.sub.6 alkyl, NR.sup.7 CON(R.sup.7).sub.2, NR.sup.7 COW, SO.sub.2 W, or W;
• R.sup.2 is C.sub.2 -C.sub.10 alkyl, C.sub.3 -C.sub.10 alkenyl, (CH.sub.2).sub.0-8 -C.sub.3-6 cycloalkyl, or (CH.sub.2)0-8phenyl unsubstituted or substituted by one to three substituents selected from C.sub.1 -C.sub.6 alkyl, nitro, Cl, Br, F, I, hydroxy, C.sub.1 -C.sub.6 alkoxy, NR.sup.7 R.sup.7, CO.sub.2 R.sup.7, CN, CONR.sup.7 R.sup.7, W, NR.sup.7 COH, NR.sup.7 COC.sub.1 -C.sub.6 alkyl, NR.sup.7 COW, SO.sub.2 W, SO.sub.2 C.sub.1 -C.sub.6 alkyl, or SC.sub.1 -C.sub.6 alkyl;
• X is a single bond, S, or O;
• m is 0-4;
• R.sup.3 is hydrogen, Cl, Br, F, I, CHO, hydroxymethyl, C.sub.1 -C.sub.6 alkyl, NR.sup.7 R.sup.7, CO.sub.2 R.sup.7, CONR.sup.7 R.sup.7, NO.sub.2, CN, phenyl, or W;
• R.sup.4 and R.sup.5 are each independently hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.6 cycloalkyl, thienyl-Y-, furyl-Y-, pyrazolyl-Y-, imidazolyl-Y-, thiazolyl-Y-, pyridyl-Y-, tetrazolyl-Y-, pyrrolyl-Y-, triazolyl-Y-, oxazolyl-Y-, isoxazolyl-Y-, or phenyl-Y-, with each aryl or heteroaryl group being unsubstituted or substituted by C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, Cl, Br, F, I, NR.sup.7 R.sup.7, CO.sub.2 R.sup.7, SO.sub.2 NHR.sup.7, SO.sub.3 H, OH, NO.sub.2, CONR.sup.7 R.sup.7, W, SO.sub.2 C.sub.1 -C.sub.6 alkyl, SO.sub.2 W, SC.sub.1 -C.sub.6 alkyl, NR.sup.7 COH, NR.sup.7 COW, or NR.sup.7 COC.sub.1 -C.sub.6 alkyl;
• Y is C.sub.1 -C.sub.6 alkyl which is straight or branched or a single bond;
• R.sup.6 is Z-tetrazol-5-yl;
• Z is a single bond, vinyl, or methylene unsubstituted or substituted by C.sub.1 -C.sub.4 alkyl, one or two benzyl groups, thienylmethyl, or furylmethyl;
• W is C.sub.n F.sub.2n+1, wherein n is 1-4;
• and
• each R.sup.7 independently is hydrogen or C.sub.1 -C.sub.6 alkyl;
• or a pharmaceutically acceptable salt thereof.